Contact Information

• Office:Room 1410B, Researching Building 18

• Email: shaoxusheng@ecust.edu.cn

• Office Phone: +86 21 64253967

• Office Fax: +86 21 64252603

Education

• 2009.07  Ph.D.  Applied Chemistry, East China University of Science & Technology, Shanghai, P. R. China

• 1999.09  M.Sc.  Polymer Science, Jinan University, Jinan, P. R. China

Group Members

Researchers:

Qi Xu, Yifei Jing, Meijun Chen, Long Wang, Kang Du, Cuncun Zhou, Yaoyao Du, Yunfan Ji, Zhi Qiao, Yujia Geng

Research Interests

• Crop protection, Development of green and novel pesticide

• Photochemistry based pesticides: photochromic insecticides, photorelease of pesticides and photosensitizers

• Pesticide toxicology, mode of action and metabolism

• Organic chemistry and synthetic methodology

Professional Experience

• 2012-2013: University of California at Berkeley, Visiting Scholar

Publication

1. Xusheng Shao, Xuhong Qian, Xiaoyong Xu, Zhong Li, Philip W. Lee. Current situation for research and development of novel pesticides in China. In Trend in Pesticide Discovery Research-Development of Safer and Environmentally Friendly Pesticides. Noriharu Umetsu, eds. 2018. (Book Chapter)

2. Zhiping Xu, Zhenhong Gao, Xusheng Shao*. Light-triggered release of insecticidally active spirotetramat-enol. Chin. Chem. Lett. 2018.DOI: 10.1016/j.cclet.2018.01.025

3. Qingqing Hou, Yifei Jing, Xusheng Shao*. Synthesis and insecticidal activities of 1,8-naphthyridine derivatives.Chin. Chem. Lett. 2017, 28, 1723-1726.

4. Zhenhong Gao, Yifei Jing, Donghui Wang, Zhiping Xu, Zhong Li, Xusheng Shao*. Photo-controlled Release of Fipronil from a Coumarin Triggered Precursor. Bioorg. Med. Chem. Lett. 2017, 27, 2528-2535.

5. Yanan Zhang, Yian Feng, Zhong Li, Xusheng Shao*. Synthesis and Insecticidal Evaluation of Phytoalexin Phenalenones Derivatives. Chin. Chem. Lett. 2017, 28, 1228-1231.

6. Xue Tian, Chao Zhang, Qi Xu, Zhong Li and Xusheng Shao*. Azobenzene-Benzoylphenylureas as Photoswitchable Chitin Synthesis Inhibitors. Org. Biomol. Chem. 2017, 15, 3320-3323.

7. Runjiang Song, Yian Feng, Donghui Wang, Zhiping Xu, Zhong Li, Xusheng Shao*. Phytoalexin Phenalenone Derivatives Inactivate Mosquito Larvae and Root-knot Nematode as Type-Ⅱ Photosensitizer. Sci. Rep. 2017, 7, 42058.

8. Ye Liu, Xinfei Chen, Xiaoyong Xu, Jiagao Cheng, Xusheng Shao*, and Zhong Li* Design, Synthesis and Insecticidal Activity of Diamides with Oxydibenzene or Diphenylamine Subunits. Lett. Drug Des. Discov. 2017, 14, 262-269.

9. Yian Feng, Minming Zou, Runjiang Song, Xusheng Shao*, Zhong Li, Xuhong Qian. Formation of 1,4,2-Dithiazolidines or 1,3-Thiazetidines from 1,1-Dichloro-2-nitroethene and Phenylthiourea Derivatives. J. Org. Chem. 2016, 81, 10321-10327.

10. Shen Li, Runjiang Song, Donghui Wang, Xue Tian, Xusheng Shao*, Zhong Li. Azopyridine-imidacloprid derivatives as photoresponsive neonicotinoids. Chin. Chem. Lett. 2016, 27, 635-639.

11. Feilong Sun, Xusheng Shao*, Zhong Li. Access of Indenofurans and Indenopyridines via Annulation of Heterocyclic Ketene Aminals, o-Phthalaldehyde and cyclic 1.3-diketones. RSC Advance 2016, 6, 15382-15389.

12. Fengjuan Zhu, Runjiang Song, Shen Li, Xusheng Shao*. In-water Synthesis of Quinazolinones from 1,1-Dichloro-2-nitroethene and Anthranilamides. Synlett 2016, 27, 2167-2170.

13. Ye Liu, Chao Lei, Xiaoyong Xu, Xusheng Shao*, Zhong Li*. Design, synthesis and insecticidal activity of biphenyl-diamide derivatives, Chin. Chem. Lett. 2016, 27, 321-324.

14. Jiling Li, Dang Wu, Xiaoyong Xu, Jin Huang, Xusheng Shao* and Zhong Li*. Design, synthesis and inhibitory activity against human dihydroorotate dehydrogenase (hDHODH) of 1, 3-benzoazole derivatives bearing amide units. Bioorg. Med. Chem. Lett. 2016, 26, 3064-3066.

15. Fengjuan Zhu, Xue Tian, Xusheng Shao*, Zhong Li. Direct Amidation of Aniline Derivatives with 1,1-Dichloro-2-nitroethene in Water. Tetrahedron Lett. 2015, 56, 5945-5949.

16. Zhiping Xu, Lina Shi, Danping Jiang, Jiagao Cheng, Xusheng Shao*, Zhong Li. Azobenzene Modified Imidacloprid Derivatives as Photoswitchable Insecticides: Steering Molecular Activity in a Controllable Manner. Sci. Rep. 2015, 5, 13962.

17. Fengjuan Zhu, Minming Zou, Xusheng Shao*, Zhong Li. On-water, Catalyst-Free and Room-temperature Construction of 2-Aryl-1,3,4-oxadiazole Derivatives from 1,1-Dichloro-2-nitroethene and Hydrazides. RSC Advance 2015, 5, 61752-61758.

18. Feilong Sun, Fengjuan Zhu, Xusheng Shao*, Zhong Li. One-pot and Three-components Synthesis of 1,8-Naphthyridine Derivatives from Heterocyclic Ketene Aminals, Malononitrile Dimer and Aryl Aldehydes. Synlett 2015, 26, 2306-2312.

19. Nanyang Chen, Xiaoqing Meng, Fengjuan Zhu, Jiagao Cheng, Xusheng Shao*, Zhong Li. Tetrahydroindeno [1’,2’:4,5] pyrrolo [1,2-a] imidazol-5(1H)-ones as Novel Neonicotinoid Insecticides: Reaction Selectivity and Substituent Effects on the Activity Level. J. Agric. Food Chem. 2015, 63, 1365-1369.

20. Jiling Li, Zhicheng Zhang, Xiaoyong Xu, Xusheng Shao*, Zhong Li*. Nematicidal Activities of Diamides with Diphenylacetylene Scaffold against Meloidogyne Incognita. Aust. J. Chem. 2015, 68, 1543-1549.

21. Jiling Li, Xiaoyong Xu, Xusheng Shao*, Zhong Li*. A Novel Colorimetric Fluoride Sensor Based on a Semi-rigid Chromophore Controlled by Hydrogen Bonding, Luminescence, 2015, 30, 1285-1289.

22. Minming Zou, Xue Tian, Nanyang Chen, Xusheng Shao*. Nematicidal Activity of Sprio and Bridged Heterocyclic Neonicotinoid Analogues against Meloidogyne incognita. Lett. Drug Des. Discov. 2015, 12, 439-445.

23. Yefeng Fan, Song Liu, Nanyang Chen, Xusheng Shao*, Xiaoyong Xu, Zhong Li*. Oxidation strategy for the synthesis of regioisomeric spiroisobenzofuranopyrroles: facile entries to spiro[isobenzofuran-1,2’-pyrrole] and spiro[isobenzofuran-1,3’-pyrrole] derivatives. Synlett 2015, 26, 393-403.

24. Nanyang Chen, Shanshan Xia, Minming Zou, Xusheng Shao*. Bridged heterocyclic neonicotinoid analogues: design, synthesis, and insecticidal activity. Res. Chem. Intermed. 2015, 41, 5293-5300.

25. Minming Zou, Nanyang Chen, Liping Ren, Xusheng Shao*, Zhong Li. A novel and facile synthesis of 2-oxo-1,2-dihydropyridine-fused 1,3-diazaheterocycles via heterocyclic ketene aminals and Knoevenagel adducts formed by phthalic anhydride and ethyl cyanacetate. Chin. Chem. Lett. 2014, 25, 1515-1519.

26. Nanyang Chen, Minming Zou, Xue Tian, Fengjuan Zhu, Danping Jiang, Xusheng Shao*, Zhong Li* Isomerization of Ninhydrin-Heterocyclic Ketene Aminals Adducts: Kinetic versus Thermodynamic Control, Solvents Dependency and Mechanism.Eur. J. Org. Chem. 2014, 28, 6210-6218.

27. Nanyang Chen, Liping Ren, Zhiping Xu, Minming Zou, Xusheng Shao*, Xiaoyong Xu, Zhong Li*. Design, Synthesis and Insecticidal Activity of Spiro Heterocycle Containing Neonicotinoid Analogues. Chin. Chem. Lett. 2014, 25, 197-200.

28. Jingwei Zhang, Xusheng Shao*, Zhong Li, Xiaoyong Xu. Bis-phenylazoneonicotinoids as Divalent Insecticides: Design, Synthesis and Activity. Lett. Drug Des. Discov. 2014, 11,150-155.

29. Liping Ren, Yanpeng Lou, Nanyang Chen, Shanshan Xia, Xusheng Shao*, Xiaoyong Xu, Zhong Li. Synthesis and Insecticidal Activities of Tetrahydroimidazo[1,2-a]pyridinones: Further Exploration on cis-Neonicotinoids. Synthetic Commun. 2014, 44, 858-867.

30. Xusheng Shao*, Shanshan Xia, Kathleen A. Durkin, John E. Casida*. Insect Nicotinic Receptor Interactions in Vivo with Neonicotinoid, Organophosphorus and Methylcarbamate Insecticides and a Synergist. Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 17273–17277.

31. Xusheng Shao, Tami L. Swenson, John E. Casida*. Cycloxaprid Insecticide: Nicotinic Acetylcholine Receptor Binding Site and Metabolism. J. Agric. Food Chem. 2013, 61, 7883–7888.

32. Xusheng Shao, Zewen Liu, Xiaoyong Xu, Zhong Li*, Xuhong Qian. Overall Status of Neonicotinoid Insecticides in China: Production, Application and Innovation. J. Pestic. Sci. 2013, 38, 1–9.

33. Xusheng Shao*, Xinglong Huang, Qian Shi, Zhong Li, Liming Tao, Gonghua Song*. Synthesis and Insecticidal Activities of Chlorothiazolyl Analogues of Nitromethylene Neonicotinoids with Tetrahydropyridine Fixed cis-Configuration. J. Heterocycl. Chem. 2012, 49, 1136–1142.

34. Xusheng Shao, Zhenjun Ye, Haibo Bao, Zewen Liu, Xiaoyong Xu, Zhong Li*, Xuhong Qian*. Advanced research on cis-neonicotinoids. Chimia 2011, 65, 957–960.

35. Xusheng Shao, Hanyan Liu, Haibo Bao, Xiaoyong Xu, Zewen Liu, Zhong Li*. The Mode of Action of a Nitroconjugated Neonicotinoid and the Effects of Target Site Mutation Y151S on its Potency. Insect Biochem. Mol. Biol.2011, 41, 440–445. (Insect Biochemistry and Molecular Biology),

36. Xusheng Shao, Philip W. Lee, Xiaoyong Xu, Zewen Liu, Zhong Li*, Xuhong Qian. cis-Configuration: A New Tactic/Rationale for Neonicotinoid Molecular Design. J. Agric. Food Chem. 2011, 59, 2943–2949.

37. Xusheng Shao, Hua Fu, Xiaoyong Xu, Xinglei Xu, Zhong Li*, Zewen Liu. Divalent and Oxabridged Neonicotinoids Constructed by Dialdehydes and Nitromethylene Analogues of Imidacloprid: Design, Synthesis, Crystal Structure and Insecticidal Activities. J. Agric. Food Chem. 2010, 58, 2696–2702.

38. Xusheng Shao, Zhiping Xu, Xianfeng Zhao, Xiaoyong Xu, Liming Tao, Zhong Li*, Xuhong Qian*. Synthesis, crystal structure, and insecticidal activities of highly congested hexahydroimidazo[1,2-a]pyridine derivatives: effect of conformation on activities.J. Agric. Food Chem. 2010, 58, 2690–2695.

39. Xusheng Shao, Xiaoyong Xu, Zhong Li *, Xuhong Qian*. Design, Synthesis and Insecticidal Activities of Novel Analogues of Neonicotinoids: Replacement of Nitromethylene with Nitro-Conjugated System.J. Agric. Food Chem. 2009, 57, 951–957.

40. Xusheng Shao, Wenwen Zhang, Yanqing Peng, Zhong Li*. cis-Nitromethylene Neonicotinoids as new nicotinic family: Sythesis,structural diersity, and insecticidal evaluation of hexahydroimidazo[1,2-a]pyridine.Bioorg. Med. Chem. Lett. 2008, 18, 6513–6516.