Department of Molecular & Cellular Pharmacology,

School of Pharmacy, East China University of Science and Technology.

Contact Information

• Office:Room 629, Researching Building 18

• Email: liujian@ecust.edu.cn

• Office Phone: +86 21 64252044

• Office Fax: +86 21 64252262

Education

• 2001.04 Ph.D. Applied Biosciences , Hiroshima Prefectural University，Hiroshima,Japan

• 1994.07  M.D. Shanghai University of Traditional Chinese Medicine,Shanghai, P. R. China

• 1989.07 M.Sc. Hubai University of Traditional Chinese Medicine, Wuhan, P. R. China

• 1981.07  Eng. School of Medicine Yangzhou University, Yangzhou, P. R. China

Professional Experience

• 2001.04-Professor , School of Pharmacy, East China University of Science and Technology

• 1996.05-1998.03, STA Fellow, Institute of Physical and Chemical Research (RIKEN), Japan

• 1995.12-1996.05, STA Fellow, Osaka Bioscience Institute（OBI）Japan

• 1994.07-1995.12, Shanghai University of Traditional Chinese Medicine

• Research Interests

• The basic applied research of the biological antioxidant materials.

• The filtration of the new anticancer materials and research their function.

Publication

• Lei KH, Tan SY, Du WP, Xu YC, Lin SC, Zheng YH, Zou FY, Xu YF, Liu JW*: 3B, a novel of photosensitizer, exhibited anti-tumor effects via mitochondrial apoptosis pathway in MCF-7 human breast carcinoma cells. Tumor Biol. 2015,36,5597-5606

• Zheng YH, Zou FY, Wang JJ, Yin GF, Le VM, Fei ZW, and Liu JW*:Photodynamic Therapy-mediated Cancer Vaccination Enhances Stem-like Phenotype and Immune Escape, Which Can Be Blocked by Thrombospondin-1 Signaling through CD47 Receptor Protein. J Biol Chem. 2015, 290, 8975-8986

• Lin SC, Lei KC, Du WP, Yang LY, Shi HY, Gao YW, Yin PH, Liang X, Liu JW*: Enhancement of oxaliplatin sensitivity in human colorectal cancer by hypericin mediated photodynamic therapy via ROS-related mechanism. Int J Biochem Cell B 2016, 71,24-34

• Zheng YH, Yin GF, Le VM, Zhang AL, Yin PH, Liu JW*, Photodynamic-therapy Activates Immune Response by disrupting Immunity Homeostasis of Tumor Cells, Which Generates Vaccine for Cancer Therapy Int J Biol Sci  2016, 12(1),120-132.

• Zou FY, Mao RR, Lei KC, Yang LY, Ding Y, Zhang P, Li JY, Liang Xin, Liu JW*: Targeted Deletion of miR-139-5p Enhances Colon Inflammation and Tumorigenesis through Negatively Regulating MAPK, NF-κB, and STAT3 Signaling Pathways. FEBS Journal, 2016,283,1438-1452.

• Xin Liang, Haiyang Shi, Liyan Yang, Cen Qiu, Shengchao Lin, Yingxue Qi, Jiyu Li, Aiguang Zhao, and Jianwen Liu*: Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells.  Br J Cancer. 2017, 116(7):903-911.

• Xin Liang*, Weixia Chen, Haiyang Shi, Xiangyu Gu, Yueqi Li, Yingxue Qi, Ke Xu*, Aiguang Zhao*, Jianwen Liu*. PTBP3 contributes to the metastasis of gastric cancer by mediating CAV1 alternative splicing. Cell Death & Disease. 2018, 11:117   

• Yueqi Li, Yiyang Chen, Cen Qiu, Xiaoying Ma, Kecheng Lei, Guoxiang Cai, Xin Liang, Jianwen Liu*: 17-allylamino-17-demethoxygeldanamycinimpeded chemotherapy through antioxidant activation via reducing ROS-induced cell death. J Cell Biochem. 2018; 1-17.

• Yingxue Qi, Wenchun Chen, Xinyu Liang, Ke Xu*, Xiangyu Gu, Fengying Wu, Xuemei Fan, Shengxiang Ren, Junling Liu, Jun Zhang6, Renhao Li, Jianwen Liu*, Xin Liang*: Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting vWF-GPIbα interaction Journal of Hematology & Oncology. 2018, 11(1):117.

• 1, Xiaoying Ma, Jiajun Liu, Jiyu Li, Yueqi Li, Van Minh Le, Shaoyu Li, Xin Liang, Lingshuang Liu,  Jianwen Liu*: miR‐139‐5p reverses stemness maintenance and metastasis of colon cancer stem‐like cells by targeting E2‐2 J Cell Physiol. 2019;1-16.

• Yuyu Zhao, Jiajun Xu, Van Minh Le, Qianyi Gong, Shaoyu Li, Feng Gao, Lei Ni*, Jianwen Liu*, Xin Liang*: EpCAM Aptamer-Functionalized Cationic Liposome-Based Nanoparticles Loaded with miR-139-5p for Targeted Therapy in Colorectal Cancer. Mol. Pharmaceutics 2019, 16, 4696-4710