Contact Information

• Office:Room 633, Researching Building 18

• Email: xin.liang@ecust.edu.cn

• Office Phone: +86 21 6425 2262

• Office Fax: +86 21 6425 2262

Education

• 2012.03 Ph.D.Biochemical Engineering, East China University of Science&Technology, Shanghai, P. R. China

• 2007.06 B.Sc.Bioengineering, East China University of Science&Technology, Shanghai, P. R. China

Professional Experience

• 2016-now   Associate Professor School of Pharmacy, East China Universtiy of Science and Technology, Shanghai, P. R. China

• 2015-2016   Instructor School of Pharmacy, East China Universtiy of Science and Technology, Shanghai, P. R. China

• 2012-2015   Postdoctoral Fellow Aflac Cancer and Blood Disorders Center, Dept of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA

Research Interests

• The mechanism of platelet membrane glycoprotein participates in the tumor metastatic process

• The interaction of miRNA in tumor metastasis and microenvironment.

Publication

1. Xu K*, Zhan Y, Yuan Z, Qiu Y, Wang H, Fan G, Wang J, Li W, Cao Y, Shen X, Zhang J, Liang X*, Yin P*. Hypoxia Induces Drug Resistance in Colorectal Cancer through the HIF-1α/miR-338-5p/IL-6 Feedback Loop.Molecular Therapy. 2019, 27(10):1810-1824.

2. Qi Y, Chen W, Liang X, Xu K*, Gu X, Wu F, Fan X, Ren S, Liu J, Zhang J, Li R, Liu J*, Liang X*. Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting vWF-GPIbα interaction. Journal of Hematology & Oncology. 2018, 11(1):117.

3. Liang X, Chen W, Shi H, Gu X, Li Y, Qi Y, Xu K^*, Zhao A^*, Liu J^*. PTBP3 contributes to the metastasis of gastric cancer by mediating CAV1 alternative splicing. Cell Death & Disease. 2018, 9:569.

4. Liang X, Shi H, Yang L, Qiu C, Lin S, Qi Y, Li J^*, Zhao A^*, Liu J^*. Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells. Br J Cancer. 2017, 116(7):903-911.

5. Liang X, Wang J, Chen W, Ma X, Wang Y, Nagao N, Weng W^*, Huang J^*, Liu J^*. Inhibition of airway remodeling and inflammation by isoforskolin in PDGF-induced rat ASMCs and OVA-induced rat asthma model. Biomed Pharmacother. 2017;95:275-286.

6. Xu K, Chen G, Li X, Wu X, Chang Z, Xu J, Zhu Y, Yin P, Liang X^*, Dong L^*. MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling. Sci Rep. 2017, 7:41718.

7. Lin S, Yang L, Shi H, Du W, Qi Y, Qiu C, Liang X^*, Shi W^*, Liu J^*. Endoplasmic reticulum-targeting photosensitizer Hypericin confers chemo-sensitization towards oxaliplatin through inducing pro-death autophagy. Int J Biochem Cell Biol. 2017;87: 54-68.

8. Chen W, Ma X, Zhang P, Li Q, Liang X^*, Liu J^*. MiR-212-3p inhibits LPS-induced inflammatory response through targeting HMGB1 in murine macrophages. Exp Cell Res. 2017, 350(2):318-26.

9. Chen W¹, Liang X¹, Syed AK, Jessup P, Church WR, Ware J, Josephson CD, Li R^*. Inhibiting GPIbα shedding preserves post-transfusion recovery and hemostatic function of platelets after prolonged storage. Arterioscler Thromb Vasc Biol. 2016, 36(9):1821-8.

10. Liang X, Syed AK, Russell SR, Ware J, Li R^*. Dimerization of glycoprotein Ib is not sufficient to induce platelet clearance. J Thromb Haemost. 2016,14: 381-6.

11. Li Q¹, Liang X¹, Wang Y, Meng X, Xu Y, Cai S, Wang Z^*, Liu J^*, Cai G^*. miR-139-5p Inhibits the Epithelial- Mesenchymal Transition and Enhances the Chemotherapeutic Sensitivity of Colorectal Cancer Cells by Downregulating BCL2. Sci Rep. 2016, 6: 27157.

12. Zou F, Mao R, Yang L, Lin S, Lei K, Zheng Y, Ding Y, Zhang P, Cai G^*, Liang X^*, Liu J^*. Targeted deletion of miR-139-5p activates MAPK, NF-kB and STAT3 signaling and promotes intestinal inflammation and colorectal cancer. FEBS J. 2016, 283(8): 1438-52.

13. Lei K, Du W, Lin S, Yang L, Xu Y, Gao Y, Xu B, Tan S, Xu Y, Qian X, Liang X^*, Liu J^*. 3B, a novel photosensitizer, inhibits glycolysis and inflammation via miR-155-5p and breaks the JAK/STAT3/SOCS1 feedback loop in human breast cancer cells. Biomed Pharmacother. 2016, 82: 141-50.

14. Zheng Y, Yin G, Le V, Zhang A, Chen S, Liang X^*, Liu J^*. Photodynamic-therapy Activates Immune Response by disrupting Immunity Homeostasis of Tumor Cells, which Generates Vaccine for Cancer Therapy. Int J Biol Sci. 2016, 12(1): 120-32.

15. Lin S, Lei K, Du W, Yang L, Shi H, Gao Y, Yin P^*, Liang X^*, Liu J^*. Enhancement of oxaliplatin sensitivity in human colorectal cancer by hypericin mediated photodynamic therapy via ROS-related mechanism. Int J Biochem Cell Biol. 2016, 71:24-34.

16. Mao R, Zou F, Yang L, Lin S, Li Y, Ma M, Yin P^*, Liang X^*, Liu J^*. The loss of MiR-139-5p promotes colitis-associated tumorigenesis by mediating PI3K/AKT/Wnt signaling. Int J Biochem Cell Biol. 2015, 69: 153-61.

17. Liang X, Russell SR, Estelle S, Jones LH, Cho S, Kahn ML, Berndt MC, Bunting ST, Ware J, Li R^*. Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site. J Thromb Haemost. 2013, 11(12): 2155-62.